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KMID : 0982820100090020057
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Journal of Lung Cancer
2010 Volume.9 No. 2 p.57 ~ p.63
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Female Lung Cancer: Re-Analysis of National Survey of Lung Cancer in Korea, 2005
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Jang Tae-Won
Jung Maan-Hong
Kim Young-Chul
Kwon Yong-Soo
Oh In-Jae
Kim Kyu-Sik
Kim Sun-Young
Ryu Jeong-Seon
Yum Ho-Kee
Lee Kwan-Ho
Yong Suk-Joong
Lee Chang-Geol
Lee Sang-Yeub
Lee Sung-Yong
Jeong Eun-Taik
In Kwang-Ho
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Abstract
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Purpose:Female lung cancers have different clinical features and therapeutic results as compared to those of male lung cancers. The aim of this study was to analyze the differences of Korean men and women with lung cancer.
Materials and Methods : We re-analyzed the results of a national survey of lung cancer conducted by the Korean Association for the Study of Lung Cancer in 2005.
Results:Of the 8,788 patients, 2,124 (24.2%) were female. The mean age at the diagnosis was 62.5 years for the females and 64.8 years for the males and the difference was significant (p＜0.001). An age ＜50 years was more frequent for the women than for the men (16.2% vs. 7.9%, respectively; p=0.001). The stages between genders were different for the patients with non-small cell carcinoma (NSCLC) (p＜0.001), but not for the patients with small cell carcinoma. The overall survival time was longer for woman than that for the man (p＜0.001). However, the male patients had longer survival for the smokers with adenocarcinoma and the smokers with squamous cell carcinoma. The never smoker female patients had a better survival time than did the smoking female patients, but the male patient’ survival was not influenced by the smoking status. The stage-specific survival rates were better for the women at all stages of NSCLC (p＜0.001). The women who received chemotherapy had a longer survival time did the men who received chemotherapy (p＜0.001).
Conclusion:Women with lung cancer were relatively overrepresented among the younger patients and they smoked less intensively, raising the question of gender- specific differences in the carcinogenesis of lung cancer. Over-representation of adenocarcinoma was observed in the women regardless of their smoking status. Women with lung cancer had a better prognosis than men; however, the smoking females showed the worst prognosis. Gender and the smoking status are clearly important factors in the therapeutic approach to lung cancer.
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KEYWORD
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Lung neoplasms, Female, Smoking, Republic of Korea
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